Novel Bishomoscalarane Sesterterpenes from the Sponge Phyllospongia foliascens
| Autor: | Evamarie O. Pordesimo, Francis J. Schmitz, Long-Mei Zeng, Sarah C. Traeger, Jing-Yu Su, Xiong Fu |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pharmacology
biology Stereochemistry Organic Chemistry Carbon skeleton Pharmaceutical Science biology.organism_classification Animal origin Analytical Chemistry Sesterterpenes Sponge Complementary and alternative medicine Drug Discovery Molecular Medicine Phyllospongia foliascens Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Natural Products. 54:421-427 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50074a012 |
| Popis: | Three new 20,24-bishomoscalarane sesterterpenes, phyllofenone B, phyllofolactone A, and phyllofolactone B, have been isolated from the Pacific sponge Phyllospongia foliascens, and their structures determined primarily by a combination of 1D and 2D nmr and mass spectrometry. Phyllofenone B with a previously unknown carbon skeleton shows cytotoxicity against the P-388 cell line (IC 50 =5 μg/ml) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|