The Effects of Illness on Urinary Catecholamines and their Metabolites in Dogs
| Autor: | David L. Panciera, G.C. Magnin-Bissel, William E. Monroe, K.N. Cameron |
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| Rok vydání: | 2010 |
| Předmět: |
education.field_of_study
medicine.medical_specialty General Veterinary business.industry Urinary system Population Physiology Urine Metanephrines medicine.disease Normetanephrine Pheochromocytoma chemistry.chemical_compound Epinephrine Endocrinology chemistry Internal medicine medicine education business Metanephrine medicine.drug |
| Zdroj: | Journal of Veterinary Internal Medicine. 24:1329-1336 |
| ISSN: | 0891-6640 |
| Popis: | Background: Urinary catecholamines and metanephrines have been proposed as a diagnostic tool for identifying canine pheochromocytomas, but the effects of critical illness on urine concentrations of catecholamines and metanephrines currently are unknown. Objectives: To examine the effects of illness on urine concentrations of catecholamines and metanephrines in dogs. Animals: Twenty-five critically ill dogs and 25 healthy age- and sex-matched control dogs. Methods: Prospective observational study. Urine was collected from healthy and critically ill dogs, and urine concentrations of epinephrine, norepinephrine, metanephrine, and normetanephrine were measured by high-performance liquid chromatography with electrochemical detection. Urinary catecholamine and metanephrine : creatinine ratios were calculated and compared between groups. Results: Urinary epinephrine, norepinephrine, metanephrine, and normetanephrine : creatinine ratios were higher in critically ill dogs when compared with a healthy control population (P= .0009, P < 0.0001, P < 0.0001, and P < 0.0001, respectively). Conclusions and Clinical Importance: Illness has a significant impact on urinary catecholamines and their metabolites in dogs. Further investigation of catecholamine and metanephrine concentrations in dogs with pheochromocytomas is warranted to fully evaluate this test as a diagnostic tool; however, the findings of this study suggest that the results may be difficult to interpret in dogs with concurrent illness. |
| Databáze: | OpenAIRE |
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