Medulloblastoma in Nordic Children. II Neurologic and Social Prognosis in Long Term Survivors
| Autor: | A. Glomstein, G. Jonmundsson, M Yssing, Stanislaw Garwicz, S. Kruus |
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| Rok vydání: | 1990 |
| Předmět: |
Medulloblastoma
Pediatrics medicine.medical_specialty medicine.diagnostic_test business.industry Mental dysfunction General Medicine medicine.disease Intellectual function Social life Quality of life Intervention (counseling) Professional life Pediatrics Perinatology and Child Health Biopsy Medicine business |
| Zdroj: | Acta Paediatrica. 79:12-19 |
| ISSN: | 1651-2227 0803-5253 |
| Popis: | Forty-four Nordic children surviving from histologically documented medulloblastoma diagnosed before the age of 15 years from 1968 to 1977 were studied by clinical investigations 5–15 years after the time of diagnosis. Thirty percent of the children suffered from major neurologic and/or intellectual late effects impairing their social life. The remaining 70 % of the children had mild or no motor, sensory, or mental dysfunction. In 30–35% of the patients the quality of life and the level of function in school and in professional life were impaired to a higher degree than was expected from the clinical observations. A favourable long term prognosis with regard to neurologic and intellectual function and to quality of life was significantly correlated to age > 10 years at diagnosis, and it was insignificantly associated with biopsy as the only primary surgical intervention and with peri-operative treatment with corticosteroids. Sex, length of diagnostic delay, and different treatment modalities did not influence the long term prognosis. |
| Databáze: | OpenAIRE |
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