Die Harnausscheidung des Hydroxyprolins bei Akromegalie
| Autor: | Solbach Hg, Irmscher K, Lepszy H, W. Wiegelmann, H. L. Krüskemper |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Hydroxyprolinuria business.industry Urinary system chemistry.chemical_element General Medicine Plasma levels Calcium medicine.disease Hydroxyproline chemistry.chemical_compound Urinary excretion Endocrinology chemistry Internal medicine Acromegaly Medicine Effective treatment business |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 101:857-861 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-0028-1104184 |
| Popis: | Urinary excretion of hydroxyproline was examined with the Hypronosticon test in 25 patients with acromegaly (13 men, 12 women) and 15 healthy persons. At the same time, plasma levels and urinary excretion of phosphorus and calcium were also measured. Patients with active acromegaly had a significantly higher urinary hydroxyproline output (32.55 +/- 8.68 mg/24 h m2) than healthy persons (12.12 +/- 2.33 mg/24 h-m2). They also excreted considerably more hydroxyproline than patients with successfully treated acromegaly. Effective treatment was proved by STH levels and good suppressibility by 100 mg glucose. Unsucessfully treated patients, on the contrary, had a raised urinary excretion of hydroxyproline (31.23 +/- 16.61 mg/24 h-m2) and high fasting plasma levels of somatotropic hormone. Hydroxyprolinuria proved, therefore, of value in assessing the development and treatment of acromegaly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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