Method development and Validation of RP-HPLC method for the Determination of Olanzapine in Bulk and Tablet Dosage form

Autor:	Sv Saibaba, Shanmuga Pandiyan P
Rok vydání:	2017
Předmět:	Pharmacology Olanzapine Chromatography Materials science Calibration curve Potassium Relative standard deviation Analytical chemistry Pharmaceutical Science chemistry.chemical_element Method development Dosage form chemistry medicine Inner diameter Pharmacology (medical) medicine.drug
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. 10:281
ISSN:	2455-3891 0974-2441
Popis:	Objective: To develop and validate reverse phase-high performance liquid chromatographic method for estimation of olanzapine in bulk and tablet dosage form.Methods: Chromatographic analysis was performed on XTerra C18 (150×3.5 mm inner diameter, 5 μm) column using a mobile phase consisting of buffer (potassium dihydrogen phosphate) and methanol (45:55% v/v) with a flow rate of 0.6 ml/minutes. The detection was carried out at 247 nm.Results: The calibration curve of olanzapine was linear in the range of 30-70 μg/ml. The mean % assay of marketed formulation was found to be 100.2%, and % recovery was observed in the range of 98-102%. Relative standard deviation for the precision study was found
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c08276077e80fe654d4173986936c5f3 https://doi.org/10.22159/ajpcr.2017.v10i5.17375 Zobrazit plný text záznamu