Tissue distribution comparison between healthy and fatty liver rats after oral administration of hawthorn leaf extract
| Autor: | Xixiang Ying, Jianguo Qu, Jingjing Yin, Wenjie Zhang, Ting-Guo Kang, Yucong Gao, Dongrui Lu |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Stomach Clinical Biochemistry Fatty liver Vitexin Hyperoside General Medicine Traditional Chinese medicine medicine.disease Biochemistry Analytical Chemistry chemistry.chemical_compound Rutin medicine.anatomical_structure Chlorogenic acid chemistry Oral administration Drug Discovery medicine Molecular Biology |
| Zdroj: | Biomedical Chromatography. 28:637-647 |
| ISSN: | 0269-3879 |
| Popis: | Hawthorn leaves, a well-known traditional Chinese medicine, have been widely used for treating cardiovascular and fatty liver diseases. The present study aimed to investigate the therapeutic basis treating fatty liver disease by comparing the tissue distribution of six compounds of hawthorn leaf extract (HLE) in fatty liver rats and healthy rats after oral administration at first day, half month and one month, separately. Therefore, a sensitive and specific HPLC method with internal standard was developed and validated to determine chlorogenic acid, vitexin-4′′-O-glucoside, vitexin-2′′-O-rhamnoside, vitexin, rutin and hyperoside in the tissues including heart, liver, spleen, kidney, stomach and intestine. The results indicated that the six compounds in HLE presented some bioactivity in treating rat fatty liver as the concentrations of the six compounds varied significantly in inter- and intragroup comparisons (healthy and/or fatty liver group). Copyright © 2013 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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