Efficacy and safety of cold versus hot snare polypectomy for small (5–9 mm) colorectal polyps: a multicenter randomized controlled trial

Autor:	Diana Joao Matias, Marina de Benito Sanz, Jorge Feito, Carla Noemi Tafur, Marta Cimavilla, Mercedes Ibañez, Antonio Guardiola-Arévalo, Laura Mata, Pilar Diez-Redondo, Jesús M. Gonzalez-Santiago, María Henar Núñez Rodríguez, Francisco Javier García-Alonso, Luis Hernández, María Isabel Garcia Martinez
Rok vydání:	2020
Předmět:	medicine.medical_specialty Abdominal pain business.industry medicine.medical_treatment Gastroenterology Asymptomatic Polypectomy Confidence interval law.invention Clinical trial Lesion Randomized controlled trial law Internal medicine medicine medicine.symptom business Adverse effect
Zdroj:	Endoscopy. 54:35-44
ISSN:	1438-8812 0013-726X
Popis:	Background Resection techniques for small polyps include cold snare polypectomy (CSP) and hot snare polypectomy (HSP). This study compared CSP and HSP in 5–9 mm polyps in terms of complete resection and adverse events. Methods This was a multicenter, randomized trial conducted in seven Spanish centers between February and November 2019. Patients with ≥ 1 5–9 mm polyp were randomized to CSP or HSP, regardless of morphology or pit pattern. After polypectomy, two marginal biopsies were submitted to a pathologist who was blinded to polyp histology. Complete resection was defined as normal mucosa or burn artifacts in the biopsies. Abdominal pain was only assessed in patients without 9 mm polyps. Results 496 patients were randomized: 237 (394 polyps) to CSP and 259 (397 polyps) to HSP. Complete polypectomy rates were 92.5 % with CSP and 94.0 % with HSP (difference 1.5 %, 95 % confidence interval –1.9 % to 4.9 %). Intraprocedural bleeding occurred during three CSPs (0.8 %) and seven HSPs (1.8 %) (P = 0.34). One lesion per group (0.4 %) presented delayed hemorrhage. Post-colonoscopy abdominal pain presented similarly in both groups 1 hour after the procedure (CSP 18.8 % vs. HSP 18.4 %) but was higher in the HSP group after 5 hours (5.9 % vs. 16.5 %; P = 0.02). A higher proportion of patients were asymptomatic 24 hours after CSP than after HSP (97 % vs. 86.4 %; P = 0.01). Conclusions We observed no differences in complete resection and bleeding rates between CSP and HSP. CSP reduced the intensity and duration of post-colonoscopy abdominal pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c07a9366411667410b2d74da5a68d343 https://doi.org/10.1055/a-1327-8357 Zobrazit plný text záznamu