Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon
| Autor: | Sevan D. Houston, Paul R. Young, Naphak Modhiran, Yongbo Xue, Paul V. Bernhardt, Glen M. Boyle, Christopher L. D. McMillan, Yuen P. Tan, Daniel Watterson, Craig M. Williams, Andrei I. Savchenko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Human influenza West Nile virus viruses Pharmaceutical Science medicine.disease_cause 01 natural sciences Analytical Chemistry Broad spectrum food Drug Discovery Botany medicine Arid zone Pharmacology Strain (chemistry) 010405 organic chemistry Chemistry Organic Chemistry Basilicum virus diseases 3. Good health 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Plant species Molecular Medicine |
| Zdroj: | Journal of Natural Products. 82:2828-2834 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3–5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. Anticancer and anti-DENV activity of 3–5 was explored, but only limited activity was observed. More extensive antiviral evaluation of stachyonic acid A (1), which was also isolated from B. polystachyon, revealed broad spectrum antiviral activity against West Nile virus (Kunjin strain, WNVKun) and human influenza viruses H1N1 and H3N2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|