| Popis: |
To study possible interactions between anticoagulants and metamizol, as assumed by Mehvar and Jamali (1981), 11 healthy caucasian male subjects were given 1 g of metamizol (dipyrone, Novalgin; Hoechst AG) orally after lowering of the prothrombin ratio by phenprocoumon (Marcumar) in 5 subjects for 7 days and by ethylbiscoumacetate (Tromexan) in 6 subjects for 9 days. Despite hourly measurements of the prothrombin ratio for 8 h after the administration of metamizol no influence on this variable could be detected. |
