The metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat
| Autor: | H. Poiger, H. R. Buser, Ch. Schlatter |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Environmental Engineering
Chromatography Trace Amounts Bile duct Health Toxicology and Mutagenesis Metabolite Public Health Environmental and Occupational Health General Medicine General Chemistry Metabolism Chlorinated Dibenzofurans Pollution Thin-layer chromatography chemistry.chemical_compound medicine.anatomical_structure Biochemistry chemistry Oral administration Biliary tract medicine Environmental Chemistry |
| Zdroj: | Chemosphere. 13:351-357 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(84)90142-5 |
| Popis: | Single doses of 2,3,7,8-tetrachlorodibenzofuran (2378-TCDF) were administered orally to bile duct cannulated rats and bile collected for up to 48 hours. The bile was analysed for the parent compound and metabolites. In organic extracts, which had been methylated and purified by TLC, 13 chlorinated metabolites were detected that were not present in the bile of untreated animals. Four of these, tetrachloromethoxy-, trichloromethoxy-and two trichlorodimethoxy-dibenzofuran isomers were present in major amounts. The remaining compounds, found only in minor or trace amounts very likely originate from other chlorinated dibenzofurans present as impurities in 2378-TCDF. No parent compound was detected in these samples. |
| Databáze: | OpenAIRE |
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