NMR1H relaxation and NOESY studies of spiperone conformational features in solution
| Autor: | Charles E. Keller, W. Robert Carper |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Spiperone
Chemistry Analytical chemistry General Chemistry Nuclear magnetic resonance spectroscopy Nuclear Overhauser effect Fluorine-19 NMR Carbon-13 NMR Crystallography Heteronuclear molecule medicine Proton NMR General Materials Science Two-dimensional nuclear magnetic resonance spectroscopy medicine.drug |
| Zdroj: | Magnetic Resonance in Chemistry. 31:566-572 |
| ISSN: | 1097-458X 0749-1581 |
| DOI: | 10.1002/mrc.1260310609 |
| Popis: | The high-field 1 H, 19 F and 13 C NMR spectra of spiperone in CDCl 3 solution mere analyzed with the aid of homonuclear (H-H-COSY) and heteronuclear (H,C-COSY) chemical shift correlation experiments. Multiple through-space intersections were identified using phase-sensitive nuclear Overhauser and exchange spectroscopy (NOESY). Proton relaxation rates and activation energies mere determined over the temperature range -60 to 50 o C. The chemical shift, NOESY and proton relaxation rate results support the formation of cyclic dimers and multiple spiperone conformations in solution |
| Databáze: | OpenAIRE |
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