PKP-004 Adverse events associated with Single Nucleotide Polymorphisms in breast cancer patients treated with docetaxel-based chemotherapy: Abstract PKP-004 Table 1
Autor: | A García Robles, V Bosó Ribelles, M Cueto Sola, J Ruiz Ramos, MJ Company Albir, MJ Herrero Cervera, SF Aliño Pellicer, JL Poveda Andrés |
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Rok vydání: | 2014 |
Předmět: |
Oncology
Pathology medicine.medical_specialty Chemotherapy education.field_of_study Cyclophosphamide business.industry medicine.medical_treatment Population Single-nucleotide polymorphism medicine.disease Breast cancer Docetaxel Internal medicine medicine Mucositis General Pharmacology Toxicology and Pharmaceutics business education Adverse effect medicine.drug |
Zdroj: | European Journal of Hospital Pharmacy. 21:A138.1-A138 |
ISSN: | 2047-9964 2047-9956 |
DOI: | 10.1136/ejhpharm-2013-000436.339 |
Popis: | Background Inter-individual differences in drug response are linked, in many cases, to single nucleotide polymorphisms (SNPs) in genes coding for drug-metabolising enzymes and transporters. Docetaxel is active for several tumour types, including breast cancer, but its use is limited by toxicity. Purpose To evaluate the associations between a panel of 86 SNPs in 32 genes and toxicities developed by breast cancer patients treated with docetaxel. Materials and methods Between June 2011 and February 2013 breast cancer patients treated with docetaxel plus cyclophosphamide ± doxorubicin who gave informed consent were genotyped. Genomic DNA was analysed by a genetic analysis platform (MassArray, Sequenom). The Hardy-Weinberg equilibrium was assessed. The association between genotypes and toxicities was assessed with Fisher’s exact test. Results Thirty-nine Caucasian women (median age: 48.2 years old; range: 33.7–75.8) were genotyped. Genotype frequencies were in Hardy-Weinberg equilibrium. 79.5% (n = 31) of the patients were treated with docetaxel plus cyclophosphamide and doxorubicin and 20.5% (n = 8) with docetaxel plus cyclophosphamide. Significant associations between SNP genotypes and toxicities are shown in the table. No associations with neurotoxicity were found. Conclusions Genetic variations in ABCB1, NOS3 and ERCC1 have been related to incidences of anaemia, neutropenia, diarrhoea and mucositis in docetaxel-treated breast cancer patients. These results need to be validated in a bigger population in order to be translated into clinical practice. No conflict of interest. |
Databáze: | OpenAIRE |
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