Cholesterol removal from plaques and elimination from the body: change in paradigm to reduce risk for heart disease
| Autor: | Siddhartha S. Ghosh, Quan Yuan, Jinghua Bie, Shobha Ghosh, Jing Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Heart disease Cholesterol Endocrinology Diabetes and Metabolism Disease Biology medicine.disease Residual risk chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Macrophage lipids (amino acids peptides and proteins) cardiovascular diseases Cardiology and Cardiovascular Medicine Inverse correlation Intracellular Lipoprotein |
| Zdroj: | Clinical Lipidology. 9:429-440 |
| ISSN: | 1758-4302 1758-4299 |
| DOI: | 10.2217/clp.14.35 |
| Popis: | Accumulation of lipid-laden macrophage foam cells in arterial wall is the hallmark of atherosclerosis, the underlying cause of cardiovascular disease (CVD). Increased uptake of cholesteryl ester-rich modified low-density lipoprotein (LDL) is thought to be responsible for lipid accumulation and strong inverse correlation exists between plasma LDL and CVD. However, despite reaching the target LDL levels significant residual risk for CVD remains. Furthermore, current therapeutic strategies do not lead to regression of existing plaques. This review discusses a change in paradigm emphasizing the importance of removal of cholesterol from macrophage foam cells and final elimination of cholesterol from the body. Intracellular processes involved in this process are described to provide insight into the development of new therapies for CVD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|