Characterization of the normal progesterone and placental protein 14 responses to human chorionic gonadotropin stimulation in the luteal phase
| Autor: | Tannia P. Cartledge, George R. Merriam, Marcelo C. Batista, Nicola Bravo, D. Lynn Loriaux, Lynnette K. Nieman |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment media_common.quotation_subject Obstetrics and Gynecology Stimulation Placental protein Biology Luteal phase Human chorionic gonadotropin Endocrinology Reproductive Medicine Internal medicine medicine Gonadotropin Saline Menstrual cycle media_common Hormone |
| Zdroj: | Fertility and Sterility. 61:637-644 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)56639-4 |
| Popis: | Objective To examine whether midluteal phase administration of the luteotrophic hormone hCG can result in higher and more stable serum levels than random sampling of P and placental protein 14 (PP14). Design Prospective controlled clinical study. Setting Normal human volunteers in an academic research environment. Participants Twenty-six fertile, regularly cycling women. Interventions Blood samples were drawn at 0, 3, 6, 9, 12, 18, and 24hours and then daily for the next 6days, after a single IM injection of 5,000IU hCG or saline given on day 5, 7, or 9 after the LH surge, as detected by rapid plasma assays. Main Outcome Measures Serum P and PP14 measurements. Results Peak P and PP14 concentrations occurred at 6hours and 5days, respectively, after hCG stimulation on luteal phase day 9. Progesterone but not PP14 levels were significantly higher and less variable after hCG than after saline administration on this day. Progesterone responses exceeded 11.0ng/mL (35.0nmol/L) in all women, suggesting that this represents the cutoff limit for normal luteal function. Because PP14 responses were highly variable and inconsistent, it was not possible to determine a threshold for normal endometrial function. Conclusions Midluteal phase administration of hCG in normal women induces consistent serum P levels>11.0ng/mL (35.0nmol/L) but highly variable PP14 responses. |
| Databáze: | OpenAIRE |
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