Integrated magnetic resonance imaging and [ 11 C]‐PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis
Autor: | David Izquierdo Garcia, Olivia Pijanowski, Marco L. Loggia, Ciprian Catana, Sabrina Paganoni, Daniel B. Chonde, Mohamad J. Alshikho, Jacob M. Hooker, Nicole R. Zürcher, Caterina Mainero, Nazem Atassi, Suma Babu, Paul Cernasov, James Chan, Beverly Reynolds |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.diagnostic_test business.industry Precentral gyrus Standardized uptake value Magnetic resonance imaging medicine.disease White matter 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Neurology Positron emission tomography Fractional anisotropy medicine Neurology (clinical) Amyotrophic lateral sclerosis Nuclear medicine business 030217 neurology & neurosurgery Primary Lateral Sclerosis |
Zdroj: | Annals of Neurology. 83:1186-1197 |
ISSN: | 1531-8249 0364-5134 |
DOI: | 10.1002/ana.25251 |
Popis: | Objective To characterize [11 C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). We have previously shown increased [11 C]-PBR28 uptake in the precentral gyrus in a small group of ALS patients. Herein, we confirm our initial finding, study the longitudinal changes, and characterize the gray versus white matter distribution of [11 C]-PBR28 uptake in a larger cohort of patients with ALS and PLS. Methods Eighty-five participants including 53 with ALS, 11 with PLS, and 21 healthy controls underwent integrated [11 C]-PBR28 PET-magnetic resonance brain imaging. Patients were clinically assessed using the Upper Motor Neuron Burden (UMNB) and the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). [11 C]-PBR28 uptake was quantified as standardized uptake value ratio (SUVR) and compared between groups. Cortical thickness and fractional anisotropy were compared between groups and correlated with SUVR and the clinical data. [11 C]-PBR28 uptake and ALSFRS-R were compared longitudinally over 6 months in 10 ALS individuals. Results Whole brain voxelwise, surface-based, and region of interest analyses revealed increased [11 C]-PBR28 uptake in the precentral and paracentral gyri in ALS, and in the subcortical white matter for the same regions in PLS, compared to controls. The increase in [11 C]-PBR28 uptake colocalized and correlated with cortical thinning, reduced fractional anisotropy, and increased mean diffusivity, and correlated with higher UMNB score. No significant changes were detected in [11 C]-PBR28 uptake over 6 months despite clinical progression. Interpretation Glial activation measured by in vivo [11 C]-PBR28 PET is increased in pathologically relevant regions in people with ALS and correlates with clinical measures. Ann Neurol 2018;83:1186-1197. |
Databáze: | OpenAIRE |
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