Histochemical Characterization of the Cutaneous Involvement of Acromegaly
| Autor: | Charles E. Kupchella, Lois Y. Matsuoka, Ana Eng, Jacobo Wortsman, John E. Dietrich |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pathology
medicine.medical_specialty integumentary system medicine.diagnostic_test business.industry Connective tissue Dermatan sulfate Glycosaminoglycan chemistry.chemical_compound medicine.anatomical_structure chemistry Dermis Reticular connective tissue Skin biopsy Hyaluronic acid Internal Medicine Medicine business Reticular Dermis |
| Zdroj: | Archives of Internal Medicine. 142:1820 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1982.00340230060013 |
| Popis: | • We evaluated the pathogenesis of skin thickening in three patients with acromegaly. Growth hormone levels were normal in one patient and were elevated in two patients. Skin biopsy specimens were obtained from the forearm. Hematoxylineosin staining showed slight epidermal thinning and, in two of the patients, a small increase in the number of fibroblasts. Selective stains for collagen, elastic, and reticular fibers disclosed normal connective tissue. The most striking abnormality was increased glycosaminoglycan deposition on the slides stained with colloidal iron. Glycosaminoglycan infiltration occurred mostly in the papillary and upper reticular dermis and was not directly related to the simultaneous growth hormone levels. Tissue digestion with specific enzymes identified hyaluronic acid, chondroitin-4- and 6-sulfate, and dermatan sulfate as the most prominent glycosaminoglycans in the dermis. The skin ultrastructure appeared to be preserved on electron microscopy. We conclude that cutaneous mucinoses is the main cause for the thickening of the skin in acromegaly. (Arch Intern Med1982;142:1820-1823) |
| Databáze: | OpenAIRE |
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