Increased postprandial homocysteinemia in a group of depressed patients
| Autor: | M. Candito, G. Darcourt, F.-E. Beaulieu, V. Aubin-Brunet, T. Chevalier, D. Pringuey |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Hyperhomocysteinemia
medicine.medical_specialty Low protein Normal diet Homocysteine business.industry Organic Chemistry Clinical Biochemistry Homocystinuria medicine.disease Biochemistry chemistry.chemical_compound Postprandial Endocrinology chemistry Internal medicine Medicine Dementia business Depression (differential diagnoses) |
| Zdroj: | Amino Acids. 12:315-321 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/bf01373012 |
| Popis: | Elevated tissue and serum concentrations of homocysteine (HCY) are associated with neuropsychiatric disorders as well as with premature occlusive vascular disease, as seen in homocystinuria. In order to study dietary-related modifications in plasma HCY, total HCY was assayed in the fasted state and 2 hr after meals in 12 depressed female patients aged 54 to 81 yr and in 12 female controls aged 50 to 85 yr. Fasting HCY was also studied in 4 patients with dementia. Postprandial HCY varied only slightly in the controls compared with their fasting values, whereas a significant increase was noted in the depressives. To study the influence of normal and low protein diets on this abnormality, fasting and postprandial HCY were investigated in 4 of the depressives after one week of a normal diet, after a week on a diet without meat, fish or eggs, and then again after return to a normal diet for one week. Persistence of the abnormal increase in postprandial HCY in 2 of these 4 patients while on the low-protein diet may have been due to an inherited defect in HCY metabolism. Folate deficiency can also cause hyperhomocysteinemia, and as folate supplements constantly lower HCY concentrations, nutritional counseling and folate therapy might prove helpful in the treatment of depression. |
| Databáze: | OpenAIRE |
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