The synthesis of [10-13C]bilirubin IXα
| Autor: | E. D. Sturrock, James R. Bull, R. E. Kirsch |
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| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 34:263-274 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580340309 |
| Popis: | The total synthesis of [10-13C]bilirubin IXα, the principal waste product of haem degradation, is described. Site specific labelling was accomplished by the Vilsmeier formylation of one of the dipyrrolic fragments using [1-13C]dimethylformamide. The penultimate dehydrohalogenation reaction was complicated by a competing elimination reaction which yielded a bridged biliverdin derivative. [10-13C]bilirubin IXα was prepared in an overall yield of 6% (from the step where 13C was introduced) with quantitative isotopic incorporation. |
| Databáze: | OpenAIRE |
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