Highly efficient synthesis of 2′-O-amino nucleosides and their incorporation in hammerhead ribozymes

Autor:	Alex B. Burgin, Alexander Karpeisky, Leonid Beigelman, Carolyn Gonzalez
Rok vydání:	1998
Předmět:	Hammerhead ribozyme biology Stereochemistry Organic Chemistry Ribozyme Oligonucleotide synthesis biology.organism_classification Biochemistry Adenosine Uridine Catalysis Phthalimide chemistry.chemical_compound chemistry Drug Discovery biology.protein medicine Trifluoromethanesulfonate medicine.drug
Zdroj:	Tetrahedron Letters. 39:1131-1134
ISSN:	0040-4039
Popis:	2′- O -Amino nucleosides were prepared from arabino nucleosides by triflate displacement with N-hydroxy phthalimide. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis, were also prepared. Incorporation of 2′- O -amino uridine into position U7 or 2′- O -amino adenosine into position A9 of a hammerhead ribozyme resulted in a slight improvement of catalytic rates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c034b3ff9e601f1705ac97289673d937 https://doi.org/10.1016/s0040-4039(97)10784-5 Zobrazit plný text záznamu Full Text from ScienceDirect