Evaluation of antiheparin activity of protamine preparations

Autor:	T. Yu. Matrosovich, N. V. Makarov, V. K. Rybin, L. V. Grigorova
Rok vydání:	1992
Předmět:	Pharmacology chemistry.chemical_classification Anticoagulant effect Arginine biology Heparin Protamine Neutralization Amino acid Biochemistry chemistry Drug Discovery medicine biology.protein Nucleic acid medicine.drug Electrostatic interaction
Zdroj:	Pharmaceutical Chemistry Journal. 26:82-85
ISSN:	1573-9031 0091-150X
Popis:	Protamines areused in clinical practice for rapid and adequate neutralization of the anticoagulant effect of heparin as its antagonists introduced into the bloodstream [3, 13]. They are nucleic proteins of sex cells of fishes with a relatively simple structure and with a very high content of the essential amino acids, in particular arginine (60-70%) [1-4]. Protamines isolated from various sources differ in the amino acid composition, and, in general, consist of two and more components [i]. Because of the characteristic feature of protamines the high content of the essential amino acids (Arg, Lis, His) and a uniform distribution of the positive charge density along the whole polypeptide chain, they are capable of inactivating heparin as a result of electrostatic interaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c0342002735a8363897b7a782b791e5d https://doi.org/10.1007/bf00773204 Zobrazit plný text záznamu Full text from SpringerLink