Nickel-Catalyzed, para-Selective, Radical-Based Alkylation of Aromatic Ketones
| Autor: | Runsheng Zeng, Yingsheng Zhao, Yu-Bo Pang, Jie Wang, Na Tao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Chemistry Ligand Oxamide Organic Chemistry Aromatic ketones chemistry.chemical_element Alkylation 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Nickel chemistry.chemical_compound Nickel catalyst Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 22:854-857 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A direct, para-selective, radical-based alkylation of aromatic ketones with alkanes has been developed using a nickel catalyst with oxamide as the ligand. Acetophenones bearing electron-withdrawing substituents were functionalized directly with simple alkanes with high para-selectivity while acetophenones with electron-donating groups were mainly para-functionalized. A mechanistic study indicated that C-H bond activation of the aromatic ring may be the rate-determining step of the reaction. |
| Databáze: | OpenAIRE |
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