Phase equilibria in dispersed solid systems of ibuprofen with piracetam and urea as hydrophilic components

Autor:	I. P. Ivanova, Yu. V. Moshchenskii, M. L. Tkachenko, L. E. Zhnyakina
Rok vydání:	2008
Předmět:	Pharmacology organic chemicals Analytical chemistry Fraction (chemistry) Ibuprofen chemistry.chemical_compound Differential scanning calorimetry chemistry Phase (matter) Drug Discovery Urea medicine Solubility Dispersion (chemistry) Eutectic system medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 42:716-718
ISSN:	1573-9031 0091-150X
Popis:	The solid dispersion systems ibuprofen-piracetam and ibuprofen-urea have been studied by differential scanning calorimetry. It is established that these systems belong to the eutectic type. The points of nonvariant equilibrium of the ibuprofen-piracetam and ibuprofen-urea systems correspond to a 65:35 and 74:26 (mol%) ratio of components, respectively. The solubility of ibuprofen from the solid binary mixtures increases with increasing fraction of very soluble components. For the ibuprofen-piracetam and ibuprofen-urea eutectic systems, the solubility of ibuprofen increases by a factor of approximately 2 and 1.53, respectively, as compared to the pure substance alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c031e14691c5032cc7207edc0664c47e https://doi.org/10.1007/s11094-009-0208-0 Zobrazit plný text záznamu Plný text ve formátu PDF