Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile
| Autor: | Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher, Jonas Helma, Marc-André Kasper, Christian P. R. Hackenberger |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Chemical Science. 14:2259-2266 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/d2sc05678j |
| Popis: | Compact phosphonamidate building blocks enable the simple construction of homogeneous DAR8 ADCs from native antibodies and hydrophobic payloads. The resulting ADCs exhibit excellent in vivo stability, clearance rates and antitumor activity. |
| Databáze: | OpenAIRE |
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