Wearable Glasses for Retinal Pigmentiosa Based on Optogenetics
| Autor: | Niall Armstrong, Patrick Degenaar, Ahmed Soltan, Walid Al-Atabany, Lionel Chaudet, Mark A. A. Neil, Pleun Maaskant |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Opsin
genetic structures Computer science Wearable computer 02 engineering and technology Optogenetics law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optics Optical imaging law Retinitis pigmentosa 0202 electrical engineering electronic engineering information engineering medicine Retina Pixel business.industry 020208 electrical & electronic engineering Retinal medicine.disease eye diseases Light intensity medicine.anatomical_structure chemistry Human eye sense organs business 030217 neurology & neurosurgery Light-emitting diode |
| Zdroj: | ISCAS |
| DOI: | 10.1109/iscas.2019.8702759 |
| Popis: | More than a decade has passed since optics and genetics came together and lead to the emerging technologies of optogenetics. The advent of light-sensitive opsins made it possible to optically trigger the neurons into activation or inhibition by using visible light. In this work we integrated virtual reality optical system with a high radiance high density microdisplay to implement a wearable device for Retinitis Pigmentosa (RP) patients. We built system to emulate the human eye and light attenuation while it passes through the eye to the retina. The average light intensity on the surface of the retina after the optical system is 1.35mW/mm2 which is above the ChR-2 stimulation level (0.7mW/mm2). The number of pixels which give light intensity above the stimulation threshold is 7128 pixel out of 8100 pixel in the microdisplay. The average efficiency of the optical system is 5.75%. So, the proposed wearable device will be able to restore vision for RP patients without the need for invasive implantable device by using optogenetics stimulation. |
| Databáze: | OpenAIRE |
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