Evaluation of Cytotoxicity of Diclofenac Sodium on L929 Fibroblasts - An in vitro Study

Autor:	Mulumoodi Rama Sowmya, S. Pradeep, P. Ajitha
Rok vydání:	2020
Předmět:	Calcium hydroxide Chemistry Diclofenac Sodium Pharmacology stomatognathic diseases chemistry.chemical_compound medicine.anatomical_structure Cell culture medicine Cytotoxic T cell MTT assay Cytotoxicity Fibroblast IC50
Zdroj:	Journal of Pharmaceutical Research International. :171-177
ISSN:	2456-9119
DOI:	10.9734/jpri/2020/v32i1830700
Popis:	The aim of the study is to evaluate comparatively the cytotoxicity of diclofenac sodium and calcium hydroxide on L929 fibroblasts. L929 fibroblast cells were cultured and grown on Dulbecco modified Eagle’s medium. Intracanal medicaments tested were Diclofenac sodium, 5.0, 7.5, 10.0 mM/ml) and calcium hydroxide. The human fibroblast cell lines cultured in Dulbecco Modified Eagle’s medium were used as control group. Cytotoxicity was evaluated by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. The results showed that there was a significant difference in cell viability as compared with the control group (P
Databáze:	OpenAIRE
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