The Effect of Pravastatin on Plasma Lipoprotein and Apolipoprotein Levels in Primary Hypercholesterolemia
| Autor: | Roger D. Blevins, James J. Maciejko, Carl Orringer, Howard S. Rosman, Lester Kobylak, Melvyn Rubenfire |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Primary hypercholesterolemia Apolipoprotein B biology business.industry medicine.medical_treatment nutritional and metabolic diseases Reductase Placebo Endocrinology Mevastatin Internal medicine Internal Medicine biology.protein medicine lipids (amino acids peptides and proteins) business Pravastatin medicine.drug Lipoprotein |
| Zdroj: | Archives of Internal Medicine. 151:2234 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1991.00400110086018 |
| Popis: | Pravastatin is a metabolic product of mevastatin and a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. It was investigated for its cholesterol-lowering properties in a double-blind, placebo-controlled, multicenter study of 82 patients with primary hypercholesterolemia. Following a 6- to 8-week dietary lead-in period, patients were randomized to twice-daily placebo or active drug for 16 weeks. Patients receiving 10 mg of pravastatin twice a day for 8 weeks experienced mean total cholesterol and low-density lipoprotein cholesterol (LDL-C) level reductions of 20% (6.85 vs 5.48 mmol/L [265 vs 212 mg/dL]) and 28% (5.17 vs 3.75 mmol/L [200 vs 145 mg/dL]), respectively. At 20 mg twice a day for an additional 8 weeks, pravastatin reduced plasma total cholesterol, LDL-C, and apolipoprotein B-100 levels by 23% (6.85 vs 5.30 mmol/L [265 vs 205 mg/dL]), 31% (5.17 vs 3.59 mmol/L [200 vs 139 mg/dL]), and 23% (118 vs 91 mg/dL), respectively. Highdensity lipoprotein cholesterol (HDL-C), HDL b -C, HDL and apolipoprotein A-I plasma concentrations increased by 11%, 60%, 7%, and 10%. Plasma triglyceride concentrations decreased in both the pravastatin- and placebo-treated patients. Pravastatin was generally well tolerated and an effective agent for the treatment of primary hypercholesterolemia. ( Arch Intern Med . 1991;151:2234-2240) |
| Databáze: | OpenAIRE |
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