Results of a pooled analysis of IOERT containing multimodality treatment for locally recurrent rectal cancer
| Autor: | G.A.P. Nieuwenhuijzen, Heidi Nelson, H.A. van den Berg, Fabian A. Holman, S.J. Bosman, Harm J. T. Rutten, Michael G. Haddock, Leonard L. Gunderson, Miranda Kusters |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Re-Irradiation
medicine.medical_specialty Multivariate analysis business.industry Colorectal cancer medicine.medical_treatment General Medicine 030230 surgery medicine.disease Surgery Radiation therapy 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine Combined Modality Therapy business Intraoperative radiation therapy Two Hundred Fifty Chemoradiotherapy |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 43:107-117 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2016.08.015 |
| Popis: | Objective Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing multimodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centres. Methods and materials Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative chemo-radiotherapy, surgery and IOERT. In uni- and multivariate analyses risk factors for local re-recurrence, distant metastasis free survival, relapse free survival, cancer-specific survival and overall survival were studied. Results Two hundred fifty one patients (44%) underwent a radical (R0) resection. In patients who had no preoperative treatment the R0 resection rate was 26%, and this was 43% and 50% for patients who respectively received preoperative re-(chemo)-irradiation or full-course radiotherapy (p Conclusions R0 resection is the most important factor influencing oncologic parameters in treatment of LRRC. Preoperative (chemo)-radiotherapy increases the chance of achieving radical resections and improves oncologic outcomes. Short waiting-times between preoperative treatment and IOERT improves the effectiveness of IOERT to reduce the chance of a local re-recurrence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect