Naturally occurring thymol based fluorescent probes for detection of intracellular free Mg2+ ion
| Autor: | Souvik Sarkar, Subhajit Guria, Susanta Adhikari, Avijit Ghosh, Animesh Sahana |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry Chemistry Monoterpene Metal ions in aqueous solution Metals and Alloys 010402 general chemistry Condensed Matter Physics biology.organism_classification 01 natural sciences Fluorescence Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials HeLa chemistry.chemical_compound Materials Chemistry Fluorescence microscope Organic chemistry Phenol Electrical and Electronic Engineering Instrumentation Thymol Intracellular |
| Zdroj: | Sensors and Actuators B: Chemical. 236:512-519 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2016.05.145 |
| Popis: | Thymol (2-isopropyl-5-methylphenol), the major constituent of ajwain, is a naturally occurring monoterpene phenol having antioxidant, anti-inflammatory and antimicrobial activities. Herein, we report 4-hydroxy-5-isopropyl-2 methylisophthalaldehyde (DFT) derived from thymol and its derivatives as selective fluorescent chemosensors for Mg2+ in aqueous medium. These probes can selectively detect Mg2+ ion and efficiently images intracellular free Mg2+ in living RAW 264.7 and HeLa cells under fluorescence microscope without any interference from common metal ions. Density Function Theory studies strongly support the experimental facts. |
| Databáze: | OpenAIRE |
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