Processing and properties of a Chitosan-Hyaluronic Acid-Biosilicate® (CHI-HA-BioS) composite for wound healing applications
| Autor: | Sônia Maria Malmonge, Leandro dos Santos, Juliana Kelmy Macário Barboza Daguano, Andrea C.D. Rodas, Lucas Rodrigues Dos Santos |
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| Rok vydání: | 2021 |
| Předmět: |
Thermogravimetric analysis
Materials science Composite number Biomedical Engineering Chitosan chemistry.chemical_compound chemistry Chemical engineering visual_art Hyaluronic acid visual_art.visual_art_medium medicine Ceramic Fourier transform infrared spectroscopy Swelling medicine.symptom Wound healing |
| Zdroj: | Research on Biomedical Engineering. 37:815-823 |
| ISSN: | 2446-4740 2446-4732 |
| Popis: | Composite biomaterials based on hydrogel biopolymers and bioactive ceramic fillers are highly attractive to wound dressing applications due to the enhanced swelling properties of hydrogel towards blood and exudates and the tissue regeneration provided by inorganic fillers. This study highlights the fabrication of Chitosan-Hyaluronic Acid-Biosilicate® (CHI-HA-BioS) composite films as a matrix for wound healing applications. Firstly, a protocol to prepare the CHI-HA-BioS composite by solvent casting was assessed. Then, the films were characterized by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM); in addition, in vitro tests were conducted to evaluate their equilibrium water content (EWC), bioactivity, and cytotoxicity. The results showed that the protocol enabled the incorporation of HA into the CHI-BioS structure of the composite, increasing its EWC and cell cytocompatibility, but reducing its bioactivity. Therefore, the characterizations of the material validated the protocol and demonstrated its efficiency. The CHI-HA-BioS composite has great potential for biomedical applications, especially in the development of dermal wound dressings. |
| Databáze: | OpenAIRE |
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