IL28Bpolymorphisms do not predict response to therapy in chronic hepatitis C with HCV genotype 5: Table 1

Autor:	Stéphanie Bibert, Houda Sabah, Sawsan Alideeb, Nabil Antaki, Dirar Abboud, Fouad Asaad, Kamel Kebbewar, Osama Baroudi, Pierre-Yves Bochud, Francesco Negro, Milad Hadad
Rok vydání:	2012
Předmět:	Response to therapy biology business.industry Hepacivirus Gastroenterology Single-nucleotide polymorphism biology.organism_classification Virology Virological response Chronic hepatitis Hepatitis C virus genotype Genotype Immunology SNP Medicine business
Zdroj:	Gut. 61:1640-1641
ISSN:	1468-3288 0017-5749
DOI:	10.1136/gutjnl-2012-302019
Popis:	We read with interest the paper by Hayes et al 1 on the impact of genetic polymorphisms near IL28B in predicting treatment response in chronic hepatitis C patients infected with hepatitis C virus genotype 1 (HCV-1). These results confirm the large, existing evidence in support of single nucleotide polymorphisms (SNPs) near IL28B being the most powerful predictors of virological response in patients infected with all major HCV genotypes, that is, 1–4.2 No data is available for HCV-5, a rare genotype neglected in clinical trials.3 We report IL28B SNP frequency and its impact on treatment outcome in 49 patients of homogeneous Caucasian ancestry, all from Syria, infected with HCV-5. Treatment included 180 μg …
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c00a4585534e0c261631279897d49392 https://doi.org/10.1136/gutjnl-2012-302019 Zobrazit plný text záznamu