Effects of long-term chronic stress on the lymphoid organs and blood leukocytes of the rat (Rattus norvegicus)
| Autor: | S. Divyashree, H. N. Yajurvedi, H. N. Sarjan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult female Physiology Spleen Biology 03 medical and health sciences Recovery period 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Lymphatic system Immunity Apoptosis Immunology medicine Animal Science and Zoology Chronic stress Lymph node 030217 neurology & neurosurgery Ecology Evolution Behavior and Systematics |
| Zdroj: | Canadian Journal of Zoology. 94:137-143 |
| ISSN: | 1480-3283 0008-4301 |
| Popis: | Exposure of adult female rats (Rattus norvegicus (Berkenhout,1769)) to restraint (1 h) and after a gap of 4 h to forced swimming exercise for 15 min daily for 12 weeks resulted in a significant decrease in (i) weight of the body and lymphoid organs (spleen, thymus, and axillary lymph node), (ii) counts of total leukocytes and their subpopulation (lymphocytes, neutrophils, monocytes, eosinophils, and basophils), and (iii) healthy cells of all lymphoid organs and a significant increase in the count of apoptotic cells in all the lymphoid organs. One month after cessation of exposure to stressors (recovery group), all the parameters did not significantly differ from stress-group rats. The results may indicate that either deleterious effects of long-term chronic exposure to stress are not reversible or the 4-week recovery period is not sufficient to restore normalcy. |
| Databáze: | OpenAIRE |
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