Highly enantiofacial protonation of prochiral lithium enolates with chiral β-hydroxy sulfoxides

Autor:	Hisashi Uda, Kunihide Hoshino, Hiroshi Kosugi
Rok vydání:	1997
Předmět:	chemistry.chemical_compound chemistry Present method Organic Chemistry Drug Discovery Enantioselective synthesis chemistry.chemical_element Organic chemistry Cyclohexanone Lithium Sulfoxide Protonation Biochemistry
Zdroj:	Tetrahedron Letters. 38:6861-6864
ISSN:	0040-4039
Popis:	Highly enantioselective protonation of prochiral lithium enolates is disclosed. The present method employed ( S,R s )-CF 3 -hydroxy sulfoxide (3b) as the chiral protonating agent, and the protonation of lithium enolates of cyclohexanone derivatives with 3b proceeded with high enantioselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c00454b8c6fa4d1e2e7e25d7e2d678c8 https://doi.org/10.1016/s0040-4039(97)01618-3 Zobrazit plný text záznamu Full Text from ScienceDirect