Designing the future of nanomedicine: current barriers to targeted brain therapeutics

Autor:	Kenneth A. Dawson, Philip M. Kelly, Diána Hudecz, Louise Rocks, Ester Polo, Luciana M. Herda
Rok vydání:	2014
Předmět:	Biomedical Engineering Medicine (miscellaneous) Bioengineering Nanotechnology Molecular systems Blood–brain barrier Brain targeting medicine.anatomical_structure Transcytosis Targeted drug delivery medicine Biological media Nanomedicine Physical and Theoretical Chemistry Neuroscience
Zdroj:	European Journal of Nanomedicine. 6
ISSN:	1662-596X 1662-5986
DOI:	10.1515/ejnm-2014-0022
Popis:	Access of therapeutic agents to the central nervous system is generally restricted by an intricate barrier system, which protects the brain and maintains homeostasis. Endogenous nutrients, however, engage with the available molecular systems and successfully cross the blood-brain barrier (BBB). One of the systems, receptor-mediated transcytosis (RMT), involves non-stereoselective vesicular trafficking and has been extensively investigated as suitable for transportation of large molecular cargos. This review focuses on recent developments in elucidating the molecular pathways that regulate RMT and the fashion in which they impact the design of therapeutic nanosystems for BBB transcytosis. The challenges of brain targeting, however, are not restricted to successful engagement with BBB receptors, also including species-specificity, selectivity and maintaining targeting capability in real biological media.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bffe14a0b992e20edaf3c0a3cf87047d https://doi.org/10.1515/ejnm-2014-0022 Zobrazit plný text záznamu