ChemInform Abstract: Triterpene and Diterpene Inhibitors of Pyruvate Dehydrogenase Kinase (PDK)

Autor:	Emma L. Kaplan, William R. Mann, Suraj S. Shetty, Christine C. Vinluan, Judit Koletar, Robert E. Damon, Jiaping Gao, Leonard J. Brand, Thomas Daniel Aicher
Rok vydání:	2010
Předmět:	Terpene Single oral dose chemistry.chemical_classification chemistry.chemical_compound Pyruvate dehydrogenase kinase chemistry Biochemistry Triterpene Amine gas treating General Medicine Diterpene Oxime Abietane
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199945217
Popis:	Several oximes of triterpenes with a 17-β hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 μmol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bffb978b3fe8103e27196390eda837ac https://doi.org/10.1002/chin.199945217 Zobrazit plný text záznamu Plný text