ANAPLASTIC TUMOR OF THE ANTERIOR MAXILLA: DIFFERENTIAL DIAGNOSIS AND IMMUNOHISTOCHEMICAL STUDY
| Autor: | Tiago Novaes Pinheiro, Luiz Carlos de Lima Ferreira, Thomas Jefferson Reis Pereira, Diogo Henrique Ohse, Eduardo Antônio Barbosa De Andrade, Yamille De Lima Souza |
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| Rok vydání: | 2020 |
| Předmět: |
Partial Maxillectomy
Pathology medicine.medical_specialty business.industry Melanoma medicine.disease Pathology and Forensic Medicine Lesion Coagulative necrosis Pleomorphism (cytology) Primitive neuroectodermal tumor medicine Immunohistochemistry Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Surgery Oral Surgery medicine.symptom Differential diagnosis business |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 129:e41-e42 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2019.06.132 |
| Popis: | The present study reports a rare case of anaplastic malignant melanoma in a 23-year-old female patient, in the anterior maxilla. On clinical examination, the lesion presented as a 5-cm sessile nodule, with brownish irregular macules on the mucosal surface, painless, with a firm consistency ranging from teeth 14 to 24 with palatal and nasal extension causing facial asymmetry and dental mobility. The computed tomography showed irregular lytic bone reabsorption, without dental involvement. The incisional biopsy followed by microscopic examination suggested primitive neuroectodermal tumor, due to the presence of round blue cells, periodic acid-Schiff (PAS)-positive clear cells, with considerable pleomorphism, atypical mitosis, hemorrhagic areas, and coagulative necrosis. Immunohistochemistry revealed high-grade epithelioid neoplasm and a diagnosis of invasive melanoma was concluded; the melanoma was positive for S-100 protein, gp100, and SOX 10 antigens. The patient underwent partial maxillectomy with no postsurgical complications after 3-month follow-up. The aggressive nature of the lesion and its prognosis are discussed. |
| Databáze: | OpenAIRE |
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