Base-promoted oxygenation of N-substituted-N-tosylhydrazines -- a convenient route to hydroxydeamination of primary amines

Autor:	Dongchu Wei, Frank S. Guziec
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Primary (chemistry) Ethanol Base (chemistry) Chemistry Organic Chemistry Deamination Oxygenation Primary alcohol Biochemistry chemistry.chemical_compound Hydrocarbon Yield (chemistry) Drug Discovery Organic chemistry
Zdroj:	Tetrahedron Letters. 33:7465-7468
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)60796-7
Popis:	Treatment of 1-substituted-1-tosylhydrazines with KOH in refluxing ethanol in the presence of atmospheric oxygen affords the corresponding alcohols in high yield. This reaction, proceeding via ethanol reduction of an intermediate hydroperoxide, provides a convenient route to hydroxydeamination of primary amines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfdfe11a0d5d2fc5bd29c111547cffc5 https://doi.org/10.1016/s0040-4039(00)60796-7 Zobrazit plný text záznamu