Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation
| Autor: | Chinonso Ishmael Ukaegbu, S. R. Shah, Hazrulrizawati Abd Hamid, Oluwaseun Ruth Alara, Z. Normaiza |
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| Rok vydání: | 2018 |
| Předmět: |
biology
Traditional medicine Chemistry DPPH General Chemical Engineering 010401 analytical chemistry Ethyl acetate 04 agricultural and veterinary sciences biology.organism_classification 040401 food science 01 natural sciences Industrial and Manufacturing Engineering In vitro 0104 chemical sciences chemistry.chemical_compound 0404 agricultural biotechnology Phytochemical MCF-7 Hypsizygus tessellatus Acetone Shimeji Safety Risk Reliability and Quality Food Science |
| Zdroj: | Journal of Food Measurement and Characterization. 13:368-382 |
| ISSN: | 2193-4134 2193-4126 |
| Popis: | Cancer management is associated with serious side-effects due to the harmful nature of radiation and chemotherapy on the body cells. These side-effects have necessitated the need for diversifying the alternative or complementary sources of cancer therapy. Natural products have been on the front line as alternative sources of anticancer agents and have attracted much attention in recent times. In this study, the anticancer activity of Hypsizygus tessellatus (white var.) caps (also known as Bunapi shimeji) extracted with acetone and ethyl acetate was evaluated in vitro against MDA-MB-231 and MCF-7 (breast cancer cell lines) and MCF-10a (Vero or normal breast cells). Likewise, the free radical scavenging and metal reducing activities of the extract were evaluated through in vitro chemical-based methods. Furthermore, the phytochemical compositions of the extracts were determined through LC–MS-QTOF-assisted mass spectroscopy. The results of this study indicated that acetone fraction had better radical scavenging activity against DPPH (IC50 = 0.76 mg/mL) and H2O2 (IC50 = 0.84 mg/mL) than ethyl acetate fraction against DPPH (IC50 = 1.10 mg/mL) and H2O2 (IC50 = 1.26 mg/mL) (p |
| Databáze: | OpenAIRE |
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