Pre-diagnostic plasma concentrations of Fibrinogen, sGPIIb/IIIa, sP-selectin, sThrombomodulin, Thrombopoietin in relation to cancer risk: Findings from a large prospective study
Autor: | Disorn Sookthai, Ruth Schübel, Theron Johnson, Peter Bugert, Laura Pletsch-Borba, Tilman Kühn, Sandra González Maldonado, Mirja E. Graf, Verena Katzke, Michael Hoffmeister, Rudolf Kaaks |
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Rok vydání: | 2018 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Colorectal cancer Hazard ratio Cancer 030204 cardiovascular system & hematology medicine.disease Fibrinogen 03 medical and health sciences 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine medicine Platelet activation Glycoprotein IIb/IIIa business Prospective cohort study medicine.drug |
Zdroj: | International Journal of Cancer. 143:2659-2667 |
ISSN: | 0020-7136 |
Popis: | While enhanced platelet activation may drive cancer progression and metastases, less is known about its role in early cancer development. Thus, we evaluated whether pre-diagnostic biomarkers of platelet activation and coagulation are related to the risks of common cancers in the prospective EPIC-Heidelberg Study using a case-cohort design. Levels of fibrinogen, soluble glycoprotein (sGP) IIb/IIIa, soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM), and thrombopoietin (TPO) were measured in baseline plasma samples of a random subcohort (n = 2,480) and incident cases of breast (n = 605), prostate (n = 543), and colorectal cancer (n = 249). Multivariable Cox regression models revealed no statistically significant associations between biomarker concentrations and any of the cancer endpoints. Subgroup analyses showed a significant inverse relationship between TPO and colorectal cancer among men, with a hazard ratio (HR, highest vs. lowest quartile) of 0.60 (95% confidence interval: 0.37,0.95), whereas no significant association was observed among women. With regard to fibrinogen levels and breast cancer risk, there was a significant positive association among nulliparous women (HR: 2.53 [95% CI: 1.21, 5.30]), but not among parous women. Overall, our data suggest that enhanced platelet activation and a pro-coagulative state may not be related to increased risks of common cancers, although studies on other potential biomarkers of platelet activation and further cancer types are needed. Findings from our subgroup analyses require further investigation, as potential underlying mechanisms are not known. |
Databáze: | OpenAIRE |
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