Enantioselective Distribution of Amino-Alcohols in a Liquid-Liquid Two-Phase System Containing Dialkyl L-Tartrate and Boric Acid

Autor:	Qing Wang, Naoko Asai, Michi Kobayashi, Hideyuki Nishizawa, Tomoko Shoji, Yoshihiro Abe
Rok vydání:	1995
Předmět:	Chloroform Aqueous solution Chromatography Enantioselective synthesis chemistry.chemical_element General Chemistry General Medicine Tartrate Boric acid chemistry.chemical_compound chemistry Drug Discovery cardiovascular system medicine Enantiomer Pindolol Boron medicine.drug Nuclear chemistry
Zdroj:	Chemical and Pharmaceutical Bulletin. 43:262-265
ISSN:	1347-5223 0009-2363
Popis:	Racemic amino-alcohols such as pindolol, propranolol, alprenolol and bucumolol enantiomers exhibited different distribution behaviors in a two-phase system consisting of a chloroform solution of didodecyl L-tartrate and an aqueous solution of boric acid. It seemed that a borate complex of the 1, 2-diol group of the tartrate and the amino-alcohol was formed in the system. In the case of pindolol, one enantiomer was preferentially extracted into the organic phase (×2.20) at equilibrium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfd962c22ec0bf9eb2700ae705cf2d6d https://doi.org/10.1248/cpb.43.262 Zobrazit plný text záznamu