| Autor: |
Stephen Macdonald, Erika Bosio, Gerben Keijzers, Sally Burrows, Moira Hibbs, Helen O’Donoghue, David Taylor, Ashes Mukherjee, Frances Kinnear, Lisa Smart, Juan-Carlos Ascencio-Lane, Edward Litton, John Fraser, Nathan I. Shapiro, Glenn Arendts, Daniel Fatovich |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1714832/v1 |
| Popis: |
INTRODUCTIONIntravenous (IV) fluid resuscitation is recommended first line therapy in septic shock, but the effectiveness and safety of this approach has been questioned. To investigate potential mechanisms of harm from IV fluid resuscitation, we measured biomarkers of endothelial glycocalyx (EG) shedding, activation of the vascular endothelium and inflammation over the first 24 hours in a clinical trial comparing a fluid-restricted resuscitation regimen to usual care with no IV fluid restriction. METHODSA planned biomarker sub-study of the REFRESH trial in which emergency department (ED) patients) with suspected sepsis and a systolic blood pressure of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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