The application of experimental design to the robustness testing of a method for the determination of drug-related impurities by capillary electrophoresis

Autor:	K. D. Altria, S. D. Filbey
Rok vydání:	1994
Předmět:	Chromatography Central composite design Chemistry Design of experiments Organic Chemistry Clinical Biochemistry Fractional factorial design Robustness testing Biochemistry Analytical Chemistry Electrophoresis Capillary electrophoresis Robustness (computer science) Voltage
Zdroj:	Chromatographia. 39:306-310
ISSN:	1612-1112 0009-5893
DOI:	10.1007/bf02274518
Popis:	Robustness testing of capillary electrophoresis methods is an important part of method validation. Appropriate use of experimental designs can be employed in this robustness testing. In this study experimental designs were used in the assessment of a capillary electrophoresis method used to determine drug related impurities. Initially a fractional factorial screening design was used to identify the critical parameters which were found to be pH and voltage. A central composite design was then performed to evaluate the response surfaces for pH and voltage which showed operation at the optimum pH and voltage values.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfd28a17af5f90ec3652001a0aec361d https://doi.org/10.1007/bf02274518 Zobrazit plný text záznamu Full text from SpringerLink