Covalently assembled ultrathin polymer nanocapsules to mimic a multienzyme-cascade antioxidative system
| Autor: | Shengda Liu, Ruizhen Tian, Fei Li, Xiaotong Fan, Junqiu Liu, Jiayun Xu, Quan Luo, Yao Xue, Feihu Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Biocompatibility biology Chemistry medicine.medical_treatment media_common.quotation_subject Glutathione peroxidase medicine.disease_cause Nanocapsules Superoxide dismutase Covalent bond Materials Chemistry medicine Biophysics biology.protein General Materials Science Internalization Oxidative stress media_common |
| Zdroj: | Materials Chemistry Frontiers. 4:2797-2804 |
| ISSN: | 2052-1537 |
| Popis: | Ultrathin selenium-containing manganese-porphyrin-based polymer nanocapsules with both superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity were successfully constructed through a covalent assembly strategy for mimicking the natural multienzyme-cascade antioxidative system. In this case, Mn-CATPyP (4,4′,4′′,4′′′-(Mn-porphyrin-5,10,15,20-tetrayl)tetrakis (1-(6-carboxyhexyl)pyridin-1-ium)) served as an SOD mimic, while Se-diamine(2,2′-selenobis(ethan-1-amine)) was designed to mimic GPx. The functionalized system shows good biocompatibility for efficient cellular internalization. In vitro experiments also demonstrated the excellent ROS-scavenging ability of the polymer nanocapsules in cell protection against oxidative stress. This artificial cooperative antioxidant model may help us to understand the natural antioxidative process. |
| Databáze: | OpenAIRE |
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