| Popis: |
Background: As the second leading cause of cancer-related death in the world, the therapeutic effect and 5-year overall survival of hepatocellular carcinoma (HCC) are not optimistic. Previous researches indicated that the disorder of PRDXs was related to the occurrence and development of cancer.Methods: In this study, analyzing through CCLE, UALCAN, HCCDB and Human Protein Atlas database databases, PRDXs not only existed in various tumor cell lines, but also had maladjusted expression on mRNA and protein levels in HCC tissues. Besides, the correlations between mRNA as well as methylation levels of PRDXs and clinical characterization were evaluated using UALCAN.Results: Kaplan-Meier Plotter demonstrated that high expression of PRDX1 or low expression of PRDX2/3 suggested poor prognosis for HCC patients. The mutation frequency, type and biological interaction network of PRDXs were obtained from c-Bioportal. By LinkedOmics, PRDXs related differential expressions genes were obtained, which were involved in several canonical pathways and certain amino acid metabolism, as well as miRNAs targeting PRDXs, some of which may effect on the progression of HCC.Conclusions: In conclusion, the disordered expression of PRDXs was correlated with prognosis of HCC patients analyzing by online tools, suggesting that PRDXs could be new molecular targets for HCC treatment and prognosis prediction. |
