Perenniporins A‒C, new cytochalasans from the fungus Perenniporia subacida with cytotoxic and anti-inflammatory activities

Autor:	Hua Guo, Ke-Hua Wang, Bo Zhang, Quanping Diao
Rok vydání:	2021
Předmět:	Perenniporia subacida biology Stereochemistry medicine.drug_class Plant Science Fungus biology.organism_classification Biochemistry Anti-inflammatory Nitric oxide chemistry.chemical_compound chemistry medicine Cytotoxic T cell Cytotoxicity Agronomy and Crop Science IC50 Biotechnology
Zdroj:	Phytochemistry Letters. 46:162-165
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2021.10.004
Popis:	Fungi are important resources for the discovery of bioactive natural products or leading compounds. In our continuous searching for bioactive metabolites from fungi, three previously undescribed cytochalasans, perennisubacins A–C (1‒3), together with three known analogues 4‒6, were isolated from the fungus Perenniporia subacida. Their structures were established by means of spectroscopic methods. Compound 1 showed cytotoxicity against SMMC-7721 with an IC50 value of 23.3 μM, while compound 3 showed cytotoxicity against A-549 with an IC50 value of 37.6 μM. In addition, compound 3 inhibited nitric oxide (NO) production with an IC50 value of 18.4 μM. This is the first report of cytochalasins from the fungus P. subacida and their bioactivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfcd20121b0e9bd77b93ad00e6efec4a https://doi.org/10.1016/j.phytol.2021.10.004 Zobrazit plný text záznamu Full Text from ScienceDirect