Epidemie D’Hantavirose Dans L’Entre-Sambre-Et-Meuse

Autor:	P. McKenna, Roger Jm, Levecque P, Bouilliez Dj, Damoiseaux P, Jan Clement, Brisbois J, Colson P, Duvivier E
Rok vydání:	1995
Předmět:	ARDS medicine.medical_specialty Pathology Respiratory distress business.industry Respiratory disease General Medicine medicine.disease Gastroenterology Systemic inflammatory response syndrome Pericarditis Internal medicine medicine Nephropathia epidemica business Hantavirus Infection Encephalitis
Zdroj:	Acta Clinica Belgica. 50:197-206
ISSN:	2295-3337 1784-3286 1992-1993
Popis:	A multihospital study allowed us to follow a total of 62 serologically proven cases of Nephropathia epidemica (NE) in the Belgian region between Sambre and Meuse during the 1992-1993 period. The clinical picture consisted of sudden high fever (100% of the cases), headache (71%), abdominal or lumbar pains (80%) and, as a less frequent but very specific sign, acute myopia (24%). Non-specific respiratory symptoms such as a non-productive cough and an abnormal lung auscultation were found in 1 case out of 4. Frequent laboratory anomalies were thrombocytopenia (69%), left-shift leucocytosis (77%), abnormal LDH (69%) and an inflammatory syndrome (86%) with levels of C-reactive protein (CRP) elevated up to a mean of 102 mg/L, often accompanied by a marked fall of total serum cholesterol and a rise of triglycerides. Impaired kidney function is the rule (84%), nevertheless serum creatinine levels remain inferior to 150 mumol/L (1.7 mg%) in 25% of the patients. As for neurological signs, 1 case of encephalitis and 1 syndrome of Guillain-Barre were observed. Relative bradycardia (< 90 bpm) was noted in 50% of the cases with fever, whereas Doppler-echocardiography detected pericarditis in 1 case, and transient impairment of the left ventricle function in 3 cases. Frequent elevation of liver enzymes (46%) confirms the observation that from now on, Hantavirus infections should be considered in the differential diagnosis of viral hepatitis. One severe case was observed with shock, diffuse intravascular coagulation and adult respiratory distress syndrome (ARDS), followed by 5 other patients presenting with marked degrees of hypoxemia and hypocapnia. We conclude that not only the causative Hantaviral serotype, but also the degree of "systemic inflammatory response syndrome" (SIRS) seems to determine the clinical picture in Hantavirus infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfc3e77ca8ab1e531c0d703586573dd0 https://doi.org/10.1080/17843286.1995.11718447 Zobrazit plný text záznamu