| Autor: |
Gayatri Amirthalingam, Meade R, Helen Parry, Christine Stephens, Sian E Faustini, Alex G. Richter, Paul Moss, Jianmin Zuo, Aarnoud Huissoon, Myah Ali, Kevin E. Brown, Bassam Hallis, Gokhan Tut, Rachel Bruton |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3825573 |
| Popis: |
Background: Extended-interval Covid vaccination regimens are now used widely in order to accelerate population coverage but the relative immunogenicity of different vaccines in older people remains uncertain. Methods: We recruited 165 participants aged 80+ years who had received a single dose of either BNT162b2 mRNA or ChAdOx1 adenovirus vaccine and studied adaptive immune responses after 5 weeks. Findings: Antibody responses against spike protein were detectable in 93% and 87% of mRNA or ChAdOx1 recipients respectively with median antibody titres of 19.3 and 19.6 U/ml (p=0.41). Spike-specific T cell responses were observed in 12% and 31% of mRNA and ChAdOx1 recipients respectively and median responses were 3-fold higher in ChAdOx1 vaccinees at 2 vs 6 spots/million respectively (p= |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
