Effect of Calcitonin on Parathyroid Hormone-Induced Vasodilation12

Autor:	Gerard A. Charbon, Elisabeth E. M. Pieper
Rok vydání:	1972
Předmět:	endocrine system medicine.medical_specialty Kidney Renal circulation Chemistry Parathyroid hormone Vasodilation Renal vasodilation Endocrinology medicine.anatomical_structure Calcitonin Internal medicine Renal blood flow medicine Antagonism hormones hormone substitutes and hormone antagonists
Zdroj:	Endocrinology. 91:828-831
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-91-3-828
Popis:	The augmentations of hepatic and renal blood flow, induced by parathyroid hormone (PTH) were assessed on anaesthetized dogs. Extracts of porcine and salmon calcitonin as well as the equivalent synthetic calcitonin preparations inhibited the PTH—induced hepatic vasodilation. Salmon calcitonin extract seemed to inhibit the PTH—induced renal vasodilation, but synthetic salmon calcitonin had no such effect. The reason for this discrepancy is not clear. Synthetic human calcitonin up to a dosage of 100 μg/kg did not antagonize die vasodilator action of PTH at all. Calcitonin decreased the maximal augmentation of arterial hepatic flow that could be induced by PTH. This suggests a non—competitive antagonism. (Endocrinology 91: 828, 1972
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bfc1a7aea4593b61cc88335b4dbe1e35 https://doi.org/10.1210/endo-91-3-828 Zobrazit plný text záznamu