Targeting Genes of Cd Induced Oxidative Stress Response in Yeasts

Autor:	Emilyia Ivanova Pisareva, Anna Kujumdzieva, Angel Angelov, Ventsislava Yankova Petrova
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Kluyveromyces lactis Candida glabrata biology Saccharomyces cerevisiae biology.organism_classification medicine.disease_cause Yeast Pichia pastoris Enzyme chemistry Biochemistry Schizosaccharomyces pombe medicine Oxidative stress Biotechnology
Zdroj:	Biotechnology & Biotechnological Equipment. 27:3716-3724
ISSN:	1314-3530 1310-2818
DOI:	10.5504/bbeq.2012.0127
Popis:	The microbial biosynthesis of nanoparticles has become one of the most studied fields of nanobiotechnology. However, exposure of cells to heavy metals and matalloides profoundly affects biological systems as it generally leads to intracellular oxidative damage and strongly depends on the cellular metabolic status. In this respect, the cadmium resistance of 7 yeast species differing in their type of glucose oxidation and energy generation (Saccharomyces cerevisiae, Candida glabrata, Schizosaccharomyces pombe, Pichia pastoris, Hansenula polymorpha, Kluyveromyces lactis and Rhodotorula graminis) was studied. It was shown that the cellular growth of S. pombe and C. glabrata was not significantly impaired when high Cd concentration was applied. Unusually elevated survival levels were also detected in H. polymorpha and R. graminis yeasts. To further investigate the cellular resistance to Cd ions, a comprehensive in silico analysis of key antioxidant enzymes were performed. Applying a computational appro...
Databáze:	OpenAIRE
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