| Popis: |
Objective This study analyzed the characteristics of early gastric cancer lymph node metastasis and survival prognosis after surgical resection in western population, and established a predictive model.MethodsPatients with stage T1a and T1b gastric cancer from 2010 to 2015 were screened from the surveillance, epidemiology and final outcome databases. Patients with multiple in situ tumors, distant metastases, and incomplete data were excluded. The risk factors for lymph node metastasis in early gastric cancer were analyzed by binary logistic regression and the chi-square test. Multivariate Cox analysis and the Kaplan-Meier test were used to evaluate the prognostic factors and survival rates of patients with early gastric cancer after surgical resection. The prediction model of lymph node metastasis and survival rate of early gastric cancer was established and verified by R software.ResultsIn 2294 patients, the lymph node metastasis rate was 14.5% (333/2294). Binary logistic multivariate regression analysis showed that tumor size (>2cm), tumor grade (III/IV), and stage T1b were risk factors for lymph node metastasis of early gastric cancer. Area under the curve (AUC) is 0.782.A predictive model was developed based on risk factors, and the model C index was 0.771, indicating that the model has good predictive ability. In addition, survival analysis of 2294 patients showed that the 5-year OS and CSS (75.4% and 88.7%) in patients without EGC were significantly higher than those with lymph node metastasis (64.3% and 72.8%) (PConclusionsWe established a reliable prediction model for lymph node metastasis of early gastric cancer and a prognostic model for early gastric cancer, which provided a good basis for clinical treatment decision. |
