Exploitation of a Candida antarctica lipase B-catalysed in situ carboxylic acid activation method for the synthesis of acetanilides

Autor:	Samridhi Lal, Timothy J. Snape
Rok vydání:	2012
Předmět:	In situ chemistry.chemical_classification biology Process Chemistry and Technology Carboxylic acid Lipase b Bioengineering biology.organism_classification Biochemistry Catalysis chemistry.chemical_compound chemistry Amide biology.protein Organic chemistry Candida antarctica Lipase Acetanilide
Zdroj:	Journal of Molecular Catalysis B: Enzymatic. 83:80-86
ISSN:	1381-1177
Popis:	An efficient biocatalytic method has been developed which provides acetanilides in good yields which are otherwise inaccessible using Candida antarctica lipase B. The process exploits the enzyme-catalysed synthesis of an acyl donor and its in situ reaction with anilines. The method is potentially useful for the synthesis of bulky acetanilides since amide formation occurs through an active site-independent step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf9c412c3b51537a5287bba2ac896ba6 https://doi.org/10.1016/j.molcatb.2012.07.007 Zobrazit plný text záznamu Full Text from ScienceDirect